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Application of organocatalysts

Our research can be divided into 6 main parts:

  1. Synthesis of cyclodextrin-cinchona organocatalysts containing thiourea or squaramide unit, and their application in asymmetric syntheses; catalyst recovery by OSN technique

  2. Synthesis of piperidine-camphor sulfonamide derivatives, and their application in Michael additions

  3. Michael addition reactions of N-Heterocycles

  4. Optimization of aza-Markovnikov additions catalyzed by different cinchona derivatives

  5. Synthesis of new axially chiral organocatalysts containing bis-1,1'-binaphthyl unit; attaching some of them to PBI membrane by click reaction

  6. Immobilization of cinchona squaramide to polyglycidyl methacrylate support and its application in asymmetric synthesis



  • Nagy, S.; Kisszékelyi, P.; Dargó, G.; Huszthy, P.; Kupai, J.: Új, cinkona alapú organokatalizátorok előállítása, alkalmazása és visszaforgatása

    Magy. Kém. Foly. 2020, 126, 152–161.
    DOI: 10.24100/MKF.2020.04.152

  • Kisszékelyi, P.; Nagy, S.; Fehér, Z.; Huszthy, P.; Kupai, J.: Membránszűréssel visszaforgatható homogén organokatalizátorok előállítása és alkalmazása

    Magy. Kém. Foly. 2020, 126, 110–120.

    DOI: 10.24100/MKF.2020.03.110

  • Kisszekelyi, P.; Nagy, S.; Fehér, Z.; Huszthy, P.; Kupai, J.: Membrane-Supported Recovery of Homogeneous Organocatalysts: A Review

Chemistry 2020, 2, 742–758. 
DOI: 10.3390/chemistry2030048

  • Nagy, S.; Fehér, Z.; Kárpáti, L.; Bagi, P.; Kisszékelyi, P.; Koczka, B.; Huszthy, P.; Pukánszky, B.; Kupai, J.: Synthesis and applications of cinchona squaramide‐modified poly(glycidyl methacrylate) microspheres as recyclable polymer‐grafted enantioselective organocatalysts

Chem. Eur. J. 2020, accepted article (IF: 4.857 in 2019)

DOI: 10.1002/chem.202001993

  • Kisszekelyi, P.; Hardian, R.; Vovusha, H.; Chen, B.; Zeng, X.; Schwingenschlogl, U.; Kupai, J.; Szekely G.: Selective Electrocatalytic Oxidation of Biomass-derived 5-Hydroxymethylfurfural to 2,5-Diformylfuran: From Mechanistic Investigations to Catalyst Recovery


ChemSusChem 2020, 13, 3127–3136. (IF: 7.962 in 2019)

DOI: 10.1002/cssc.202000453


  • Nagy, S.; Fehér, Z.; Dargó, G.; Barabás, J.; Garádi, Z.; Mátravölgyi, B.; Kisszékelyi, P.; Dargó, Gy.; Huszthy, P.; Höltzl, T.; Balogh, G. T.; Kupai, J.: Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring

Materials 201912, 3034 (IF: 3.057)

DOI: 10.3390/ma12183034

  • Nagy, S.; Dargó, G.; Kisszekelyi, P.; Fehér, Z.; Simon, A.; Barabás, J.; Höltzl, T.; Mátravölgyi, B.; Karpati, L.; Drahos, L.; Huszthy, P.; Kupai, J.: New enantiopure binaphthyl-cinchona thiosquaramides: synthesis and application for enantioselective organocatalysis  


New J. Chem. 2019, 43, 5948-5959.  (IF: 3.288) 

DOI:  10.1039/C8NJ06451B

  • Kisszekelyi, P.; Alammar, A.; Kupai, J.; Huszthy, P.; Barabas, J.; Holtzl, T.; Szente, L.; Bawn, C.; Adams, R.; Szekely, G.: Asymmetric synthesis with cinchona-decorated cyclodextrin in a continuous-flow membrane reactor

J. Catal. 2019, 371, 255-261. (IF: 7.888) 

DOI: 10.1016/j.jcat.2019.01.041


  • Nagy, S.; Kisszékelyi, P.; Kupai, J.: Synthesis and Application of Thiosquaramides and Their Derivatives: A Review

Period. Polytech. Chem. Eng. 2018, 62, 467-475. (IF: 1.382) 

DOI: 10.3311/PPch.12851

  • Kisszékelyi, P.; Nagy, S.; Tóth, B.; Zeller, B.; Hegedűs, L.; Mátravölgyi, B.; Grün, A.; Németh, T.;  Huszthy, P.; Kupai, J.: Synthesis and recovery of pyridine- and piperidine-based camphorsulfonamide organocatalysts used for Michael addition reaction.

Period. Polytech. Chem. Eng. 2018, 62, 489-496. (IF: 1.382) 

DOI: 10.3311/PPch.12719

  • Nagy, S; Fehér, Z.; Kisszékelyi, P.; Huszthy, P.; Kupai, J.: Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition.

New J. Chem. 2018, 42, 8596-8602. (IF: 3.069) 

DOI: 10.1039/C8NJ01277F

  • Didaskalou, C.; Kupai, J.; Cseri, L.; Barabas, J.; Vass, E.; Holtz, T.; Szekely, G.: Membrane-Grafted Asymmetric Organocatalyst for an Integrated Synthesis–Separation Platform.

ACS Catal. 20188, 7430–7438. (IF: 12.221)

DOI: 10.1021/acscatal.8b01706


  • Fődi, T.; Didaskalou, C.; Kupai, J.; Balogh, G. T.; Huszthy, P.; Szekely, G.:Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis.

    ChemSusChem 2017, 10, 3435-3444. (IF: 7.116)

DOI: 10.1002/cssc.201701120

  • Kupai, J.; Razali, M.; Buyuktiryaki, S.; Kecili, R.; Szekely, G.: Long-term stability and resuability of molecularly imprinted polymers

    Polym. Chem. 2017, 8, 666–673. (IF: 5.375)

DOI: 10.1039/C6PY01853J


As of September/October 2018, this highly cited paper received enough citations to place it in the top 1% of the academic field of Chemistry based on a highly cited threshold for the field and publication year. Data from Essential Science Indicators


  • Kupai, J.; Kisszékelyi, P.; Rojik, E.; Dargó, G.; Hegedűs, L.; Bezzegh, D.; Maszler, P.; Szabó, L.; Németh, T.; Balogh, Gy. T.; Huszthy, P.: Synthesis and determination of pKa values of new enantiopure pyridino- and piperidino-18-crown-6 ethers, Arkivoc, 2016, iv, 130–151.

Arkivoc 2016, iv, 130–151. (IF: 1.031)

DOI: 10.3998/ark.5550190.p009.592

  • Fődi, T.; Kupai, J.; Túrós, G.; Németh, T.; Rojik, E.; Balogh, G. T., Huszthy, P.: Application of Flow
    Chemistry to Macrocyclization of Crown Ethers. 

J. Flow Chem. 2016, 6, 297–301.

DOI: 10.1556/1846.2016.00033

  • Cseri, L.; Fődi, T.; Kupai, J.; Balogh, G.; Garforth, A.; Szekely, G.: Membrane-assisted catalysis in
    organic media.

Adv. Mater. Lett. 2016, 8, 1094-1124.

DOI: 10.5185/amlett.2017.1541


  • Kupai J.; Rojik E.; Huszthy P.; Székely Gy.: Role of Chirality and Macroring in Imprinted Polymers with Enantiodiscriminative Power

    ACS Appl. Mater. Interfaces 2015, 7, 9516–9525. (IF: 7.145)

DOI: 10.1021/acsami.5b00755



This subgroup is the part of the Supramolecular Chemistry Research Group at BUTE, Department of Organic Chemistry and Technology. Its group leader is: Peter Huszthy, PhD, DSc, Member of HAS.
Our main partners are:

  • Gyorgy Szekely, PhD, KAUST, Saudi and The University of Manchester, UK 

  • Matyas Milen, PhD, Egis Pharmaceutical Plc. 

  • Gyorgy T. Balogh, Gedeon Richter Pharmaceutical Plc. 

  • Peter Abranyi-Balogh, PhD, HAS-Research Center

  • Bela Pukanszky, PhD, DSc, Member of HAS, BUTE, Department of Physical Chemistry and Material Science

  • Emília Csiszar, PhD, BUTE, Department of Physical Chemistry and Material Science

  • Bela Matravolgyi, PhD, BUTE, Department of Organic Chemistry and Technology

  • Tamas Hergert, PhD, BUTE, Department of Organic Chemistry and Technology

  • Tibor Holtzl, PhD, BUTE, Department of Inorganic and Analytical Chemistry

  • Viola Horvath, PhD, BUTE, Department of Inorganic and Analytical Chemistry

  • Andras Simon, PhD, BUTE, Department of Inorganic and Analytical Chemistry

  • Bela Koczka, PhD, BUTE, Department of Inorganic and Analytical Chemistry

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